Sepsis Clinical Trial
Official title:
Target Attainment of TDM-guided Continuous Infusion of Piperacillin/Tazobactam and Cefepim in Critically Ill Patients: a Prospective Observational Study
Although alternative dosing strategies can improve antimicrobial exposure in critically ill
patients, the high PK variability in this population means that some may still receive
sub-optimal antibiotic exposure leading to unfavourable clinical outcomes.
Therapeutic drug management (TDM) guided dosing is the only safe and effective way to ensure
that all critically ill patients achieve therapeutic antimicrobial exposures and to minimise
the likelihood of toxicity.
For experts, TDM should be a standard of care, in particular for β-lactams. Nevertheless,
because of the assay method for β-lactams and the need for bioanalytical experts, delays in
obtaining results frequently occurred. These barriers, combined with difficulties in the
interpretation of TDM results, need to be addressed in order to increase its routine
utilization. Consequently, study aiming at identify which subgroup of patients or infection
are more likely to benefit from TDM are urgently warranted This prospective observational
study aimed at evaluating target attainment of piperacillin/tazobactam (PIP/TAZ) and cefepim
(CEF) with the use of a Therapeutic Drug Monitoring (TDM) in critically patients during the
routine care
n/a
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