Sepsis Clinical Trial
Official title:
EARLY-MYO-SEPSIS (EARLY Assessment of MYOcardial Injury in Sepsis Patient) Registry
The diagnosis and pathophysiology of sepsis-induced cardiac dysfunction remain unknown. This registry is to evaluate characteristics of sepsis patients by multi-modalities imaging, including echocardiography, cardiovascular magnetic resonance imaging in 300 patients in 5 sites. Subjects will be followed up to 2 years.
Approximately 20-30 million patients worldwide suffer from sepsis every year, which is
increasing at the rate of 8% to 13% per year. It is possible that sepsis progress to multiple
organ dysfunction in the early stage, with a fatality of 30% to 60%. Myocardium is one of the
most vulnerable tissue under the abnormal 'inflammation storm'.Cardiac dysfunction is one of
the important predictors for mortality of sepsis.Patients with myocardial depression have an
apparently higher mortality rate (70%) as compared with septic patients without cardiac
impairment (20%).
Although several trials had explored the diagnosis and treatment of sepsis-induced cardiac
dysfunction, the effective characteristic depict and effective therapy remain incompletely
understand.
This is a prospective, multi-center, non-randomized, observational registry study of sepsis
patients that undergo multi-modality imaging.
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|---|---|---|---|
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