Sepsis Clinical Trial
Official title:
Effect of a Novel Extracorporeal Cytokine Apheresis Method on Endocan, Copeptin and Interleukin-6 Levels in Sepsis: an Observational Prospective Study.
Background: There is still an evident need for useful biomarkers and effective therapeutic approaches regarding the challenging management of sepsis. The aim of the study is to evaluate the effect of each Cytosorb hemoadsorption therapy course on blood levels of inflammatory biomarkers of sepsis including endocan, copeptin, interleukin-6, procalcitonin, C-reactive protein.
This observational prospective study included patients, who were diagnosed with sepsis and
treated in the reanimation ICU of Gaziantep University Hospital with Cytosorb therapy between
June 1st, 2016 and June 30th, 2017. Sepsis was diagnosed according to The Third International
Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
Exclusion criteria of the study were: (i) cardiovascular disease, (ii) multiple traumas,
(iii) malignancies, (v) incomplete clinical data.
Approval of the ethical committee (ethical committee approval number 2018/04-02) was
obtained. Written informed consent was taken from each patient or their next-of-kin. Patient
demographics including age, gender, and origin of sepsis were recorded. Arterial blood
samples were taken from patients before and immediately after the Cytosorb therapy course.
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