Sepsis Clinical Trial
Official title:
The Effect of Albumin Supplementation on the Inflammatory and Oxidative Stress Markers in Septic Patients
There is currently no uniform target for serum albumin levels in some pathological
conditions, but recent studies have shown that serum albumin concentrations, disease
severity, and mortality rates have been linked. Although the exact mechanism is unclear,
serum albumin levels may have a protective effect on the potential antioxidant effect of
maintaining physiological homeostasis and its anti-inflammatory effects. The indication and
efficacy of parenteral albumin therapy in the care of patients in critical condition has long
been a hot topic. Although previous mortality endpoint studies were negative, it is not
certain that they can be used clearly in intensive care. According to earlier research,
albumin is a very important circulating antioxidant. It is believed that early
suplementattion of albumin may have a beneficial effect on oxidative stress and inflammation
in septic patients.
The aim of our study is to investigate changes in parameters (inflammation, oxidative stress)
that can be directly influenced by the administration of albumin in septic cases in need of
intensive care. Also in our earlier, relatively small number of studies, chemiluminescence
analysis of non-enzymatic total antioxidant capacity showed an increase in total antioxidant
capacity in septic patients. The proposed study may also clarify the background of
pathophysiological changes behind this phenomenon.
There is currently no uniform target for serum albumin levels in some pathological
conditions, but recent studies have shown that serum albumin concentrations, disease
severity, and mortality rates have been linked. Although the exact mechanism is unclear,
serum albumin levels may have a protective effect on the potential antioxidant effect of
maintaining physiological homeostasis and its anti-inflammatory effects. The indication and
efficacy of parenteral albumin therapy in the care of patients in critical condition has long
been a hot topic. Although previous mortality endpoint studies were negative, it is not
certain that they can be used clearly in intensive care. According to earlier research,
albumin is a very important circulating antioxidant. It is believed that early
suplementattion of albumin may have a beneficial effect on oxidative stress and inflammation
in septic patients.
The aim of our study is to investigate changes in parameters (inflammation, oxidative stress)
that can be directly influenced by the administration of albumin in septic cases in need of
intensive care. Also in our earlier, relatively small number of studies, chemiluminescence
analysis of non-enzymatic total antioxidant capacity showed an increase in total antioxidant
capacity in septic patients. The proposed study may also clarify the background of
pathophysiological changes behind this phenomenon.
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