Multiple Biomarkers in ICU Sepsis Patients

Sepsis Clinical Trial

Official title:

Prognostic Value of Early Oxidative Stress Biomarkers in Patients With Sepsis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03802136
• Other study ID #: 2018062
• Status: Recruiting
• Start date: December 30, 2018
• Est. completion date: June 2019

Study information

• Verified date: January 2019
• Source: Zhongnan Hospital
• Contact: zhiyong peng, professor
• Phone: 008618672396028
• Email: pengzy5[@]hotmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality. Oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. Some biomarkers would be able to identify who will recover and not recover better than serum creatinine. Thus, a combining oxidative stress biomarkers are needed to predict the occurrence or progression of AKI in critically ill patients.

Description:

Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality. Oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. Research on AKI has focused on new damage biomarkers for early detection of AKI and worsening of renal function. Some biomarkers would be able to identify who will recover and not recover better than serum creatinine. Thus, a combining functional and damage markers as well as oxidative stress biomarkers are needed to predict the occurrence or progression of AKI in critically ill patients. Therefore, this prospective, observational study will be conducted in Mainland China

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 120
• Est. completion date: June 2019
• Est. primary completion date: June 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• sepsis patients in appropriate age

Exclusion Criteria:

• ever blood transfusion ever CPR(cardiopulmonary resuscitation)

Related Conditions & MeSH terms

• AKI
• Sepsis
• Sepsis, Severe
• Septic Shock
• Shock, Septic
• Toxemia

Locations

Country	Name	City	State
China	Zhongnan Hospital of Wuhan University	Wuhan	Hubei

Sponsors (1)

Lead Sponsor	Collaborator
Zhongnan Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	presence of AKI	Use serum creatinine or urine output(The KDIGO Guidelines 2012) to asess whether AKI happens to the studied subjects within a week after admission to ICU	a week after admission to ICU
Primary	Death of the patients	Mortality of the studied patients	2 weeks after admission to ICU
Secondary	Use serum creatinine to assess renal function of the patients	Concetration of serum creatinine	the 1 day when the patients admitted to ICU