Sepsis Clinical Trial
Official title:
Cognitive Processing in Patients Surviving Delirium. Neuropsychological, EEG and Structural Brain Correlates.
The research program explores how delirium influenced brain function in patients surviving delirium and septic encephalopathy from a non neurological specialized ICU cohort from 2013 to 2015 in Rigshospitalet (Glostrup).
The overall aim is to understand the pathophysiological mechanism in delirium and septic
encephalopathy and its consequences.
For this purpose we will:
1. Provide extensive cognitive testing. These results provide the basis for categorization
of patients surviving septic encephalopathy and delirious patients.
2. First, the investigators will examine if the differences in cognitive function is
reflected in the ability of the brain to generate high-frequency electrical oscillations
that accompany and underlie perception, attention, cognition, memory formation and
retrieval. It will be performed by carrying out continuous EEG (cEEG) and by examination
of steady-state evoked cognitive EEG responses.
3. Second, the investigations will examine MRI, structural and diffusion tensor imaging
sequences. Hippocampal, thalamic, amygdala, lentiform nucleus and cingulate cortex
volumes will be determined bilaterally and will be compared between individuals with
healthy brain aging and patients that survived delirium.
4. Third, the investigators will assess plasma markers of free radical production.
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