Sepsis Clinical Trial
Official title:
The Role of Post-traumatic Inhibition of the Innate and Adaptive Immune System in the Development of Infectious Complications in Severely Injured Patients
Patients admitted to the Intensive Care Unit after severe injury are prone to suffer from
infectious complications and even sepsis. Despite tremendous efforts the etiology of this
increased susceptibility to infectious pathogens is incompletely understood. Clinical signs
and symptoms as well as current diagnostic clinical tests (WBC, CRP, cytokines,
interleukines) lack sensitivity or specificity for adequate prediction of the development of
infectious complications or sepsis.
Neutrophil granulocytes, cells of the innate immune system, play an important role in the
defence against invading bacterial pathogens and are crucial in preventing fulminant
infections. For successful eradication of a bacterium neutrophils need to exert specific
functions: chemotaxis, migration, phagocytosis, degranulation and production of radical
oxygen species. Much research has focused on the effect of trauma on neutrophil's individual
capacities to kill bacteria with conflicting interpretations as a result. For adequate
determination of the neutrophil's capacity to eradicate bacteria from tissue of trauma
patients we developed novel in-vitro assays in which neutrophils are tested for all of these
functions combined. This assay allows us to identify dysfunctional neutrophils adequately.
The main focus of this study is the determination of the functionality of aberrant
neutrophils circulating in the peripheral blood of severly injured following trauma.
n/a
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