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Clinical Trial Summary

Progranulin blood concentrations in patients with sepsis will be analysed in relation to disease status in order to validate progranulin as a biomarker for sepsis. Patients undergoing cardiac surgery will serve as controls.


Clinical Trial Description

Single nucleotide polymorphisms with known effects on Progranulin plasma concentrations will be assessed in a separate analysis. Expression levels of microRNAs isolated from plasma, circulating exosomes and blood cells will be determined by next-generation sequencing to characterize epigenetic influences on progranulin plasma levels. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03280576
Study type Observational
Source Ludwig-Maximilians - University of Munich
Contact
Status Completed
Phase
Start date April 2015
Completion date June 2019

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