Sepsis Clinical Trial
Official title:
Platelet Immune Responses in Aging and Influenza and Sepsis (INVACS)
Aging is associated with immunosenescence and impaired host defense mechanisms, contributing
to influenza-related morbidity and mortality. Preliminary data demonstrate that the platelet
transcriptome is markedly different between healthy subjects and influenza patients.
Interferon-induced transmembrane proteins (IFITM) family members are among the transcripts
significantly increased in platelets during influenza and expression of IFITM-3 is impaired
in elderly subjects, a pattern associated with increased mortality. This study will build on
these data and investigate if aging influences the expression of platelet IFITM family
members in patients with influenza and sepsis.
This study will prospectively determine if aging alters the induction of (IFITMs) in
platelets from hospitalized influenza and sepsis patients. The study will also determine if
diminished expression of IFITM family members correlates with an increased risk of adverse
outcomes in older influenza and sepsis patients.
This will be a prospective observational cohort study comparing older (ageā„65) and younger (age<65) influenza and sepsis patients. ;
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