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NCT01976884 Clinical Trial

Expression and the Clinical Significance of Neutrophil PD-L1 During Sepsis

Sepsis Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01976884
Other study ID # NeutrophilPD-L1
Secondary ID
Status Completed
Phase N/A
First received October 30, 2013
Last updated October 30, 2013
Start date June 2011
Est. completion date January 2013

Study information
Verified date October 2013
Source Changhai Hospital
Contact n/a
Is FDA regulated No
Health authority China: National Natural Science Foundation
Study type Observational

Clinical Trial Summary

Immunosuppression is the leading cause of death in septic patients. Neutrophils are classical components of innate immunology, but recent studies showed that neutrophils might display antigen presenting function and inhibit lymphocyte proliferation by expressing programmed cell death 1 ligand 1 (PD-L1). Whether neutrophils express PD-L1 and its role in immunosuppression during sepsis remain unclear.

Recruitment information / eligibility
Status Completed
Enrollment 71
Est. completion date January 2013
Est. primary completion date January 2013
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- patients with severe sepsis

- patients with sepsis after PCNL for infectious kidney stone

- patients with pancreatic cancer

- healthy volunteers

Exclusion Criteria:

- patients with immunodeficient diseases

- patients who accept glucocorticoid or immunosuppressant

- patients with an age older than 18 years

- patients providing the informed consent

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Changhai Hospital

Outcome
Type Measure Description Time frame Safety issue
Primary PD-L1 level on neutrophils PD-L1 level on neutrophils was compared between different populations. within 24h after recruitment No
Secondary 28-day mortality 28 days after diagnosis of sepsis No
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