Sepsis Clinical Trial
Official title:
The AVERT Sepsis Investigation: Assessment of Variability in Early Resuscitation and Treatment of Sepsis
The overall objective of this study is to utilize heart rate variability and respiratory
rate variability in patients with sepsis to predict clinical deterioration and death.
Our specific objectives are:
1. To study the ability of a change in composite variability (∆CVI) assessment to act as a
prognostic aid in predicting disease progression in sepsis.
2. To study the effect that standard resuscitation interventions will have on the
direction and magnitude of ∆CVI in patients with sepsis.
B. Hypotheses H1: In the initial resuscitation of sepsis, a low or declining multi-parameter
composite variability index (CVI) over 4 hours will predict a significant increase in the
combined outcome of overt shock, organ dysfunction, and mortality.
H2: In the initial resuscitation of sepsis, low volume fluid resuscitation (<20 cc/kg) over
4 hours will be associated with a low or declining CVI.
n/a
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
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Phase 3 | |
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Phase 2 | |
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Phase 4 | |
| Recruiting |
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Phase 2 | |
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|
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| Recruiting |
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| Completed |
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| Completed |
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| Not yet recruiting |
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Phase 3 |