Sepsis Clinical Trial
Official title:
Repository for Samples Collected From Sepsis and Postresuscitation Patients in Emergency Intensive Care Unit
The objective of this study is to find a new therapeutic strategy by investigating the serial serum samples of patients with sepsis or postresuscitation state.
Status | Recruiting |
Enrollment | 500 |
Est. completion date | December 2028 |
Est. primary completion date | December 2028 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 16 Years and older |
Eligibility | Inclusion Criteria: - Age over 16 years old - Admitted to ICU - Diagnosed as having sepsis or as postresuscitation status - Definition of sepsis: 2 or more SIRS criteria + infection is suspected - Definition of postresuscitation status: Survived from non-traumatic cardiac arrest Exclusion Criteria: - refusal to participate - DNAR status |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Seoul National University Hospital | Seoul |
Lead Sponsor | Collaborator |
---|---|
Seoul National University Hospital |
Korea, Republic of,
Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001 Jul;29(7):1303-10. doi: 10.1097/00003246-200107000-00002. — View Citation
Cohen J. The immunopathogenesis of sepsis. Nature. 2002 Dec 19-26;420(6917):885-91. doi: 10.1038/nature01326. — View Citation
Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med. 2007 May;35(5):1244-50. doi: 10.1097/01.CCM.0000261890.41311.E9. — View Citation
Schneider A, Bottiger BW, Popp E. Cerebral resuscitation after cardiocirculatory arrest. Anesth Analg. 2009 Mar;108(3):971-9. doi: 10.1213/ane.0b013e318193ca99. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | 1-month mortality | All cause mortality within 1-month | 1 month | |
Secondary | Hospital mortality | All cause mortality during hospitalization | until hospital discharge, an expected average of 2 weeks | |
Secondary | ICU length of stay | Until ward transfer or discharge, an expected average of 7 days | ||
Secondary | Favorable neurologic outcome | Favorable neurologic outcome is used for outcome measure in postresuscitation patients only. Favorable neurologic outcome means cerebral performance category 1 and 2. This outcome is measured at discharge and 6-month after admission. |
at discharge, an expected average of 2 weeks and at 6-month |
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