The Changes of CD4+T Lymphocyte Subsets in Septic Patients

Sepsis Clinical Trial

Official title:

The Role of CD4+T Lymphocyte Subsets in Cell Immunity in Patients With Sepsis

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT01494389
• Other study ID #: 20111013-008
• Status: Active, not recruiting
• Phase: N/A
• First received: December 16, 2011
• Last updated: December 16, 2011
• Start date: August 2011
• Est. completion date: March 2012

Study information

• Verified date: July 2011
• Source: Chinese PLA General Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Ethics Committee
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to explore the value of CD4+T lymphocyte subsets in cell immunity in the patients with sepsis.There are immunoparalysis in septic patients,the important player is the change of CD4+T lymphocyte,this immunoparalysis state contribute to the illness progress and outcome. Comprehend the change regularity of septic patients' cell immunity can guide fiter and correcter treatment.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 0
• Est. completion date: March 2012
• Est. primary completion date: March 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Male and female aged 18 years old and over;

• Fulfilled at least two criteria of systemic inflammatory response syndrome (a) core temperature higher than 38 °C or lower than 36 °C (b)respiratory rate above 20/min, or PCO2 below 32 mmHg (c) pulse rate above 90/min, and (d) white blood cell count greater than 12,000/µl or lower than < 4,000/µl or less than 10% of bands.

• Clinically suspected infection;

Exclusion Criteria:

• were under 18 years of age;

• were refused by the patients or his/her familiality;

• were suffering from acquired immunodeficiency syndrome,virlhepatitis,autoimmune diseases and hematology;

• use medicine which can affect immune system,such as Glucocorticoid and Immunosuppressant

• died within 24h after being taken into the ICU, or refused to get involved in the study, or gave up treatment during the period of observation

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Sepsis
• SIRS(Systemic Inflammatory Response Syndrome)
• Systemic Inflammatory Response Syndrome

Locations

Country	Name	City	State
China	Chinese PLA General Hospital	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Chinese PLA General Hospital

Country where clinical trial is conducted

China,