Sepsis Clinical Trial
Official title:
Dynamic Cerebrovascular Autoregulation During Sepsis and Sepsis-associated Delirium
Verified date | April 2013 |
Source | Johannes Gutenberg University Mainz |
Contact | n/a |
Is FDA regulated | No |
Health authority | Germany: Ethics Commission |
Study type | Observational |
The aim of the study is to correlate the dynamic cerebrovascular autoregulation by patients with sepsis with a sepsis-associated delirium.
Status | Completed |
Enrollment | 30 |
Est. completion date | March 2011 |
Est. primary completion date | December 2010 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - clinical symptoms of sepsis, severe sepsis and septic shock - possibility for measurement of transcranial doppler ultrasound - age over 18 years Exclusion Criteria: - preexisting cerebrovascular disease - preexisting immunological disease - traumatic brain injury - intracranial infectious disease - pregnancy |
Observational Model: Case-Only, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Germany | University medical centre Mainz | Mainz |
Lead Sponsor | Collaborator |
---|---|
Johannes Gutenberg University Mainz |
Germany,
Schramm P, Klein KU, Falkenberg L, Berres M, Closhen D, Werhahn KJ, David M, Werner C, Engelhard K. Impaired cerebrovascular autoregulation in patients with severe sepsis and sepsis-associated delirium. Crit Care. 2012 Oct 4;16(5):R181. doi: 10.1186/cc116 — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Disturbed cerebrovascular autoregulation correlates with sepsis associated delir | The Index of autoregulation (Mx) was measured and correlated with the clinical incidence of a sepsis associated delir | 1 year | No |
Secondary | Correlation between inflammatory parameters and disturbed cerebrovascular autoregulation | 1 year | No | |
Secondary | Correlation between inflammatory parameters and sepsis-associated delirium | 1 year | No |
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