Sepsis Clinical Trial
Official title:
Citrate Pharmacokinetics in Healthy Individuals and Critically Ill Patients and the Application of Regional Citrate Anticoagulation in Continuous Renal Replacement Therapy(RCA-CRRT).
1. To compare the differences of citrate pharmacokinetics in healthy individuals and
critically ill patients as well as the influential factors.
2. To validate a pharmacokinetic model which has been established in a formal paper.
3. To create a safe and effective RCA-CRRT protocol.
| Status | Recruiting |
| Enrollment | 40 |
| Est. completion date | September 2011 |
| Est. primary completion date | December 2010 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | Both |
| Age group | 18 Years to 80 Years |
| Eligibility |
Inclusion Criteria: - healthy individuals, none-pregnant - diagnosed with acute renal failure according to RIFLE criteria - ARF with hepatic insufficiency - ARF with MODS or sepsis - within informed consent Exclusion Criteria: - used drugs with citrate within one week - infused with blood,plasma or platelet or undergone plasma exchange therapy within 48 hours - serious alkalosis with PH>7.55 - serious lactic acidosis - not in resuscitation state |
Observational Model: Case Control, Time Perspective: Prospective
| Country | Name | City | State |
|---|---|---|---|
| China | Huashan hospital | Shanghai |
| Lead Sponsor | Collaborator |
|---|---|
| Huashan Hospital | Shanghai Scientific and technology committe |
China,
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