Sepsis Clinical Trial
Official title:
Diagnostic and Predictive Value of Circulating microRNAs During Sepsis
Verified date | May 2013 |
Source | Changhai Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | China: Ethics Committee |
Study type | Observational |
MicroRNA has been demonstrated to play a crucial role in regulating cell processes. Recently, microRNA was identified to exist in human serum or plasma, and it might be related to certain diseases. Several microRNAs are involved in sepsis, such as miR-146, miR-155, and so on. But whether serum miR-146 is present in serum of septic patients remains unknown. The present study was designed to identify the existence of specific microRNAs, which might be new markers for sepsis and its prognosis.
Status | Completed |
Enrollment | 100 |
Est. completion date | June 2009 |
Est. primary completion date | April 2009 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - patients who develop sepsis and undergo abdominal surgery - patients who develop SIRS after cardiac surgery with cardiopulmonary bypass Exclusion Criteria: - patients with a primary diagnosis of acute pancreatitis - patients with cirrhosis or renal dysfunction - patients with dyscrasia - patients with autoimmunity diseases - patients with severe cardiac and pulmonary diseases - patients with hematological diseases - patients who had organ dysfunction after cardiac surgery with cardiopulmonary bypass |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
China | Changhai Hospital, Second Military Medical University | Shanghai |
Lead Sponsor | Collaborator |
---|---|
Changhai Hospital |
China,
Wang JF, Yu ML, Yu G, Bian JJ, Deng XM, Wan XJ, Zhu KM. Serum miR-146a and miR-223 as potential new biomarkers for sepsis. Biochem Biophys Res Commun. 2010 Mar 26;394(1):184-8. doi: 10.1016/j.bbrc.2010.02.145. Epub 2010 Feb 24. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Relative amount of circulating microRNAs | On the second day of diagnosis of sepsis in ICU | Yes | |
Secondary | Serum levels of CRP and IL-6 | On the second day of diagnosing sepsis | Yes | |
Secondary | Apache II score and death | On the second day of diagnosis of sepsis | Yes |
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