Sepsis Clinical Trial
Official title:
Investigation of Arterial Blood Pressure-complexity and Its Relation to Outcome in Comparison Between Cardiac Surgery Versus Non-cardiac Surgery Septic Patients
Arterial blood pressure (ABP) is regulated by multiple, interconnected feedback loops
resulting in a variable and complex time course. According to the "decomplexification theory
of illness", disease is characterised by a loss or impaired function of feedback loops
resulting in a decreased complexity of the ABP-time course and an impaired adaptability of
the cardiovascular system.
Decomplexification of physiologic parameters has been shown to occur in coronary heart
disease, Parkinson's and Hodgkin's disease, and in subarachnoid hemorrhage, but has not been
evaluated in sepsis.
This study is intended to test the hypothesis that complexity of ABP
- is lower in cardiac surgery versus non-cardiac surgery septic patients,
- decreases as severity of sepsis increases to severe sepsis and septic shock,
- is associated with outcome three month after sepsis.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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|---|---|---|---|
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