Sepsis Clinical Trial
Official title:
Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock
Patients with severe infection can develop very low blood pressure. There are many
mechanisms leading to this, and one of them appears to involve a hormone called vasopressin.
In children as compared to adults, the mechanism and response to low blood pressure are
different for reasons that are not clear. One possibility is the difference in the
production and/or response to vasopressin. Vasopressin has become part of the treatment of
children with low blood pressure in the setting of severe infection, when other treatment
has failed, but its use is on the basis of animal and adult studies. The exact timing and
dose is uncertain.
In this research study, the patients will receive standard treatment for sepsis and septic
shock, and the investigators will measure the blood levels of vasopressin and a related
compound called copeptin (both are required to understand the mechanism of control
involved). Blood will need to be taken from patients without any sepsis so as to be able to
compare the values in health and in sickness. The patient groups the investigators have
chosen for this are those children who will have blood taken anyway as part of their routine
care. The aim of this study is to develop an understanding of the body's hormonal response
(with respect to vasopressin) to severe infection in children. The long-term aim is to
improve the care of critically ill children with severe infection by using the most
appropriate dose of vasopressin at the most appropriate time.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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