Sepsis Clinical Trial
Official title:
Prevention of Central Veinous Device Related Sepsis Relapse With Taurolidine in Patients on Parenteral Nutrition in Long-term Home
Home parenteral nutrition (HPN) is a validated technique for patients with various
intestinal disease leading to chronic malabsorption or obstruction, whatever the aetiology.
Intravascular catheter-related bloodstream infections (CRBSI) is the more frequent
complication of patients with HPN and an important cause of morbidity and mortality in these
patients. Moreover, CRBSI often recur after a first treatment of the catheter with a
combination of an antibiotic lock on the catheter and systemic intravenous antibiotics. In
more than 50 % of the cases, another CRBSI will occur in a median delay of 5 months.
The aim of the study is to evaluate the efficacy of a taurolidine lock secondary prophylaxis
on CRBSI recurrence in HPN patients.
Study population is separated in 2 groups, the first one receiving the Taurolock and the
second one receiving a placebo. This is a randomized double-blind six-month study.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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