Sepsis Clinical Trial
Official title:
The Evaluation of the Effect of Nitroglycerine Versus Placebo on the Microcirculation by Means of SDF Imaging in Septic Patients on the ICU
The purpose of this study is to evaluate the effect of nitro-glycerine on the
microcirculation (smallest vessel type) in patients with severe sepsis and septic shock.
Nitro-glycerine is a well known medicine in cardiology and is used to improve circulation.
In this ICU the investigators use nitro-glycerine to improve the organ perfusion; but it's
no common therapy in the rest of the world. The investigators now compare nitro-glycerine
and placebo by looking to the sublingual microcirculation by a small camera (SDF imaging).
This study starts at admission of the patient on the ICU. In the next 24 hours the patient
receives nitro-glycerine or placebo (randomised). At time = 0, ½, 2, 12 and 24 hour we
evaluate the microcirculation by SDF imaging and monitoring of hemodynamic parameters.
Informed consent is obtained of the relatives.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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