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NCT00360048 Clinical Trial

Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers

Sepsis Clinical Trial

Official title:
Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00360048
Other study ID # 2006-000246-39
Secondary ID EK-Nr.: 014/2006
Status Completed
Phase N/A
First received August 2, 2006
Last updated December 10, 2007
Start date August 2006

Study information
Verified date December 2007
Source Medical University of Vienna
Contact n/a
Is FDA regulated No
Health authority Austria: Federal Ministry for Health and Women
Study type Observational

Clinical Trial Summary

The aim of this study is to determine if oxytocin administration is able to blunt LPS induced increase of cytokines (TNF-α) and if there is a change in the endocrine response after lipopolysaccharide administration in humans.

Recruitment information / eligibility
Status Completed
Enrollment 10
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- Men aged 18 years or older with no disease history

- Written informed consent

Exclusion Criteria:

- Receiving any medication

- Probands who suffer from infectious disease

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Intervention

Drug:
• oxytocin

Locations
Country Name City State
Austria Medical University of Vienna Vienna

Sponsors (1)
Lead Sponsor Collaborator
Medical University of Vienna

Country where clinical trial is conducted

Austria, 

Outcome
Type Measure Description Time frame Safety issue
Primary TNF-alpha six hours No
Secondary ACTH, cortisol, procalcitonin, IL-1ra, IL-4, IL-6, MIP-1alpha, MIP-1 beta, MCP-1, IP-10, VEGF, body temperature, BNP, Ghrelin, six hours No
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