Sepsis Clinical Trial
Official title:
Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis
Aims of the study were to find vascular markers of inflammation and endothelial damage during the course of severe sepsis in septic patients and the effects of treatment with anti-inflammatory medication (such as Drotregocin alfa (activated)). Another aim is to find new markers and gene polymorphisms for prognosis and mortality of patients with severe sepsis. The hypothesis is that higher plasma concentrations of certain markers in septic patients are associated with a higher mortality rate.
Status | Completed |
Enrollment | 105 |
Est. completion date | December 2011 |
Est. primary completion date | December 2011 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - SIRS-Criteria - Proven Infection - One sepsis-induced organ-failure - Adults <18 years old Exclusion Criteria: - Anemia - Pregnancy - Blood donor in the last 3 month |
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Country | Name | City | State |
---|---|---|---|
Germany | 1. Medical Department | University hospital Mannheim | Mannheim |
Lead Sponsor | Collaborator |
---|---|
Universitätsmedizin Mannheim |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | New Prognostic markers for septic patients | until 300 Patients are included | No |
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