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NCT00141973 Clinical Trial

Time Course of Procalcitonin and C Reactive Protein in Septic Patients Under Treatment With Corticosteroids

Sepsis Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00141973
Other study ID # CE1408
Secondary ID
Status Completed
Phase N/A
First received September 1, 2005
Last updated May 13, 2008
Start date November 2004
Est. completion date December 2005

Study information
Verified date May 2008
Source Ospedale Regionale Bellinzona e Valli
Contact n/a
Is FDA regulated No
Health authority Switzerland: Swissmedic
Study type Observational

Clinical Trial Summary

A systemic treatment with corticosteroids has been advocated for various bacterial infectious diseases. Since the production of CRP is down-regulated by corticosteroids, a smaller increase or a more rapid decrease of this acute phase protein will:

1. suggest attenuated systemic inflammation, but

2. does not necessarily reflect adequate therapy of the infection.

For several reasons (good diagnostic tool for sepsis, induction not decreased by immunosuppressive therapy), procalcitonin could be a better marker for activity of sepsis in patients under corticosteroids. As this issue has not yet been examined the investigators will prospectively study the time-course of PTC and CRP in a well-defined septic patient group, that in adjunction to antibiotic therapy also received systemic corticosteroid treatment and compare it to a similar group without corticosteroid treatment.

Recruitment information / eligibility
Status Completed
Enrollment 0
Est. completion date December 2005
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 50 Years to 80 Years
Eligibility Inclusion Criteria:

- Acute exacerbation of chronic obstructive pulmonary disease (COPD) due to bacterial pneumonia

Exclusion Criteria:

- Chronic systemic use of corticosteroids

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Switzerland Ospedale Regionale Bellinzona e Valli Bellinzona Ticino

Sponsors (2)
Lead Sponsor Collaborator
Ospedale Regionale Bellinzona e Valli Brahms SA, D-16761 Hennigsdorf bei Berlin

Country where clinical trial is conducted

Switzerland, 

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