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Observed Pharmacokinetic of Piperacillin/Tazobactam Compared to Amikacin in ICU — OPTIMA  

Sepsis Clinical Trial

Official title:
Observed Pharmacokinetic of Piperacillin/Tazobactam in ICU Patients Compared to Therapeutic Drug Monitoring of Amikacin

Clinical Trial Summary

The pharmacokinetics of antimicrobials is profoundly modified in Intensive care unit (ICU) patients. To adapt the treatment, it is recommended to measure blood levels of antibiotics. Some antibiotics, such as amikacin, are easy to monitor, while for other molecules, such as piperacillin/tazobactam, the drug monitoring is more difficult to obtain. These two molecules have similar physicochemical characteristics (hydrophilicity) and therefore have closed pharmacokinetic properties. OPTIMA is a study aiming at criteria will be used to judge whether the pharmacokinetic (PK) parameters of amikacin are predictive of those of piperacillin and tazobactam.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03990467
Study type Interventional
Source Hospices Civils de Lyon
Contact Arnaud FRIGGERI, MD
Phone 478865647
Email arnaud.friggeri@chu-lyon.fr
Status Recruiting
Phase N/A
Start date January 28, 2021
Completion date January 28, 2023
View Details
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