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Metabolism of Branched-chain Amino Acids in Monocyte/Macrophage During Sepsis

Sepsis Syndrome Clinical Trial

Official title:
Metabolism of Branched-chain Amino Acids in Monocyte and Macrophage During Sepsis

Clinical Trial Summary

The current project was designed to examine the metabolic level of branched-chain amino acids in plasm and monocyte/macrophage, and its role in immune dysfunction during sepsis.

Clinical Trial Description

In this study, the investigators will collect the peripheral blood of 1,3,7,14 day after diagnose of sepsis. Then, the concentration of branched-chain amino acids(BCAAs) in monocytes and plasma, and the expression of BCAAs metabolic enzymes in monocytes will be determined. Additionally, the inflammatory cytokines, e.g., Interleukin-1β (IL-1β), Tumor necrosis factor-α (TNF-α), Interleukin-10 (IL-10）, the chemokines macrophage inflammatory proteins 1α and 1β (MIP-1α and 1β) in the peripheral blood and the phagocytic function of monocytes will also be detected. The current project was designed to examine the metabolic level of branched-chain amino acids in plasm and monocyte/macrophage, and its role in immune dysfunction during sepsis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03842371
Study type Observational
Source West China Hospital
Contact
Status Not yet recruiting
Phase
Start date February 11, 2019
Completion date February 28, 2022
View Details
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