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Sensitivity and Specificity clinical trials

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NCT ID: NCT05114551 Recruiting - Critical Care Clinical Trials

ICU Predictive Score of WEaning Success in Patients At Risk of Extubation Failure

I-SWEAR
Start date: September 28, 2021
Phase:
Study type: Observational

Observational study in two medical-surgical intensive care units of the Clermont-Ferrand University Hospital to develop a composite score for prediction of 72h-extubation failure in patients at risk of extubation failure.

NCT ID: NCT02978131 Completed - Tuberculosis Clinical Trials

Histopathological Techniques and PCR on Tissues Included in Paraffin for the Diagnosis of Tuberculosis

Start date: May 2015
Phase:
Study type: Observational

Tuberculosis (TB) remains a major public health problem nowadays. About 30% of the world population is infected with Mycobacterium tuberculosis. There is an increase in the number of cases of classic tuberculosis in developing countries, even if number of cases are declining in developed countries. However, in developed countries this decrease is counterbalanced by the emergence of multidrug resistant (MDR) strains of the bacteria. There are also latent forms (1/3 of the world population) of the infection that can be reactivated in one case out of ten. Each year, about 2 million people die of tuberculosis and 9 million new cases are identified, including about 500,000 cases of MDR TB. The spread of this disease as well as the increasing number of cases of MDR tuberculosis, reinforce the need for research and development of strategies of diagnosis and management of this affection. Nowadays, the culture is the gold standard for the TB diagnosis but this technique needs at least three weeks to be performed. The objective of this study is to evaluate the sensitivity and specificity of histopathological and molecular techniques (PCR) on paraformaldehyde fixed and embedded in paraffin tissues for a faster diagnosis of tuberculosis in current practice, in order to administrate an efficient treatment as soon as possible.