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Seizures clinical trials

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NCT ID: NCT03474770 Active, not recruiting - Clinical trials for Focal Impaired Awareness Seizures

BIS-001-ER for the Treatment of Adult Focal Impaired Awareness Seizures

FIAS
Start date: April 10, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to examine safety signals and demonstrate seizure reduction in adults with FIAS treated with BIS-001ER as an add-on therapy in an in-patient and out-patient study design.

NCT ID: NCT03441867 Active, not recruiting - Epilepsy Clinical Trials

Neuroimaging Biomarker for Seizures

NIBMSZS
Start date: September 15, 2017
Phase: N/A
Study type: Interventional

This multi-site study will examine patients with epilepsy (ES) following head injury [i.e., posttraumatic epilepsy (PTE)] and posttraumatic psychogenic Non-epileptic seizures (PNES) and will compare them to patients with traumatic brain injury (TBI) who do not have seizures using functional neuroimaging.

NCT ID: NCT03313362 Active, not recruiting - Clinical trials for Psychogenic Seizures

Detecting PNES With Single-channel sEMG

Start date: November 3, 2017
Phase: N/A
Study type: Interventional

This is a prospective, comparative, multicenter study of subjects being admitted for standard of care therapy in Epilepsy Monitoring Units in the Veteran's Affair (VA) Medical Centers.

NCT ID: NCT03207685 Active, not recruiting - Epilepsy Clinical Trials

Generalized Seizure Detection And Alerting In The EMU With The Empatica Embrace Watch And Smartphone-Based Alert System

Start date: June 30, 2017
Phase: N/A
Study type: Interventional

To demonstrate safety and effectiveness of the Embrace device in identifying convulsive seizures (CS) and notifying a caregiver during patient hospitalization at an epilepsy monitoring unit (EMU).

NCT ID: NCT03191058 Active, not recruiting - Depression Clinical Trials

Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression

CREST-MST
Start date: June 26, 2018
Phase: N/A
Study type: Interventional

This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for depression. Even with multiple medication trials, 30 - 40% of patients will experience a pharmacologically resistant form of illness. The ineffectiveness of current treatments for major depressive disorder (MDD) coupled with the economic burden associated with the disorder engenders a need for novel therapeutic interventions that can provide greater response and remission rates.

NCT ID: NCT03181945 Active, not recruiting - Seizures Clinical Trials

Duration of Anti-convulsant Therapy for Acute Symptomatic Seizure in Acute Encephalitis Syndrome

Start date: May 1, 2016
Phase: N/A
Study type: Interventional

There are no guidelines or studies evaluating duration of anti-epileptic drugs in central nervous system infections. The duration of anti-epileptic drug is extrapolated from traumatic brain injury in which duration of 1 weeks to 3 months is suggested. So the investigators plan to conduct this study to decide the optimal duration of anti-epileptic drug in acute symptomatic seizure in central nervous system infections

NCT ID: NCT03169751 Active, not recruiting - Epilepsy Clinical Trials

An Exploratory Trial Using sEMG to Differentiate PNES From Epileptic Seizures

Start date: September 1, 2017
Phase:
Study type: Observational

This is an observational study of subjects receiving standard of care therapy, while admitted to Epilepsy Monitoring Unit, Department of Neurology, General Hospital Hietzing with Neurological Center Rosenhügel. Additional monitoring provided by the SPEAC System will be compared to the gold standard, vEEG. The SPEAC System is being evaluated while being used in adjunct to standard of care.

NCT ID: NCT03013348 Active, not recruiting - Clinical trials for Convulsion, Non-Epileptic

Automated Identification of Psychogenic Nonepileptic Seizures

Start date: January 2017
Phase:
Study type: Observational

A retrospective validation study of a post-processing method intended to identify psychogenic nonepileptic seizures

NCT ID: NCT02962414 Active, not recruiting - Clinical trials for Tuberous Sclerosis Complex

Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment

Start date: June 8, 2017
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the long-term safety in patients with TSC and refractory seizures who are currently receiving everolimus treatment in the Novartis-sponsored EXIST-3 study and who are determined to be benefiting from continued treatment as judged by the investigator at the completion of EXIST-3

NCT ID: NCT02819427 Active, not recruiting - Epilepsy Clinical Trials

Concomitant High-resolution Recording of Haemodynamic and Electrical Activities of Children With Typical or Atypical Absence Seizures

Absence
Start date: April 2013
Phase:
Study type: Observational

This study, conducted in children with typical or atypical "absence" epilepsy, will consist of noninvasive recording of the metabolic activity of the brain concomitantly with electroencephalographic recording during seizures without the need for any additional examination. This examination will be performed by combining near-infrared spectroscopy (NIRS) optical imaging and Electroencephalography (EEG) in a simultaneous High-Resolution (HR) recording. Surface electroencephalography (EEG) is a valuable tool to assess neuronal dysfunction from a functional point of view and is used in the routine follow-up of epileptic children. Optical imaging is a recent and promising medical imaging technique, which uses near-infrared light. This rapid, noninvasive and harmless quantitative technique can be easily used at the child's bedside or in the ward and provides metabolic information on brain functioning.