Epilepsy Clinical Trial
Official title:
Quantitative Susceptibility Mapping Biomarker, Brain Structure and Connectome Associated With Cerebral Cavernous Malformation Related Epilepsy and Outcome After Surgery
Cerebral cavernous malformation (CCM)-related epilepsy (CRE) impairs the quality of life in patients with CCM. Patients could not always achieve seizure freedom after surgical resection of the lesion, suggesting an inadequate treatment and evaluation of the epileptogenic zone or network. Iron deposition in cerebral cavernous malformations has been postulated to play an important role in triggering CRE. Quantitative susceptibility mapping (QSM), as an optimal in vivo imaging technique to quantify iron deposition, is employed to analyze the iron quantity in CCM patients with epilepsy and further combined with brain structural and connectome analysis, to describe the difference between CCMs with and without epilepsy. In vivo biomarkers predicting CRE risk in CCM natural history and CRE control outcome after CCM surgical resection will be further identified to improve management strategy.
The CRESS study is a prospective observational study of imaging biomarker for cerebral
cavernous malformation (CCM) related epilepsy (CRE) risk in natural history or after surgical
resection. This project, funded by the National Nature Science Foundation of China, will be
performed in two sites: Bejing Tiantan Hospital, Capital Medical University and Peking
University International Hospital, which cover the south and north part of Beijing. Bejing
Tiantan Hospital is also the China National Clinical Research Center for Neurological
Diseases and the largest neurological center with high volume of patients all over the
nation.
Study overview: Each participants will be followed for 5 year since enrollment. Epilepsy will
be tracked with serial video EEG recordings and clinical investigations performed annually.
Besides medical history of the patients, data from seizure diary and MR imaging studies
(including quantitative susceptibility mapping, diffusion tensor imaging and three
dimension-T1 weighted imaging), will be collected. Blood samples and tissue samples of
surgical resected lesion for biomarkers studies will also be collected in all participants of
the project. The data obtained in participants of CCM with or without epilepsy will be
compared.
Sample size: Investigators plan to enroll 200 CCM patients in 24 months and follow up for 5
years. Based upon the preliminary results and extensive literature review, investigators
predict that about 50% of participants will undergo surgical treatment, while 25% of
participants remain suffering from seizure after treatment.
Study endpoints: The primary clinical endpoint of this study is a collection of a set of
clinical, molecular, and MRI data in all participants.
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