Doxapram as an Additive to Propofol Sedation in Sedation for ERCP

Status Completed

Clinical Trial Summary

Sedation is needed in order to complete endoscopic retrograde cholangiopancreatography (ERCP) to alleviate discomfort and pain during the procedure. This is usually achieved with use of opioids and/or sedative agents such as benzodiazepines or propofol. Traditionally benzodiazepines have been used but nowadays propofol is becoming the drug of choice for sedation during ERCP.

The problem with propofol sedation is the fact that it may case cardiorespiratory depression and there is no antidote for this like there is for benzodiazepines. Cardiovascular depression can usually be easily counteracted with drugs that are used to raise blood pressure or heart rate during general anesthesia but respiratory depression remains a problem.

The aim of this study is to try to counteract the respiratory depression caused by propofol sedation using an old respiratory stimulant doxapram as opposed to placebo using a double blind randomized protocol.

The investigators hypothesis is that boluses and an infusion of doxapram will alleviate the respiratory depression caused by propofol sedation.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Supportive Care

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02171910
Study type	Interventional
Source	Helsinki University Central Hospital
Contact
Status	Completed
Phase	Phase 4
Start date	October 2016
Completion date	December 2016

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04498598` - Structural Modification In Supraglottic Airway Device	N/A
Completed	`NCT05532670` - N600X Low Saturation Accuracy Validation
Enrolling by invitation	`NCT04106401` - Intravascular Volumes in Hypoxia During Antarctic Confinement	N/A
Recruiting	`NCT05883137` - High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
Not yet recruiting	`NCT05817448` - Hypoxia-induced Autophagy in the Pathogenesis of MAP
Recruiting	`NCT02661152` - DAHANCA 30: A Randomized Non-inferiority Trial of Hypoxia-profile Guided Hypoxic Modification of Radiotherapy of HNSCC.	Phase 3
Terminated	`NCT02801162` - Evaluation of Accuracy and Precision of a New Arterial Blood Gas Analysis System Blood in Comparison With the Reference Standard	N/A
Completed	`NCT02943863` - Regional Ventilation During High Flow Nasal Cannula and Conventional Nasal Cannula in Patients With Hypoxia	N/A
Not yet recruiting	`NCT02201875` - Intrinsic Periodic Pattern of Breathing	N/A
Completed	`NCT02105298` - Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study)	N/A
Completed	`NCT01922401` - Inverse Ratio Ventilation on Bariatric Operation	N/A
Active, not recruiting	`NCT01681238` - Goal-directed Therapy in High-risk Surgery	N/A
Completed	`NCT01463527` - Using Capnography to Reduce Hypoxia During Pediatric Sedation	N/A
Completed	`NCT01507623` - Value of Capnography During Nurse Administered Propofol Sedation (NAPS)	N/A
Withdrawn	`NCT00638040` - The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor Progression	N/A
Active, not recruiting	`NCT06097754` - Intermittent Exogenous Ketosis (IEK) at High Altitude	N/A
Completed	`NCT04589923` - The VISION-Acute Study
Completed	`NCT05044585` - Evaluation of RDS MultiSense® in Desaturation Analysis in Healthy Volunteers	N/A
Completed	`NCT03659513` - The Effect of ECMO on the Pharmacokinetics of the Drugs and Their Clinical Efficacy
Completed	`NCT03221387` - Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients	N/A