Clinical Trials Logo
  1. Home
  2. Seasonal Affective Disorder
  3. NCT00269633

Research Study of Treatment for Winter Depression With Different Colors of Light

Seasonal Affective Disorder Clinical Trial

Official title:
Optimizing Light Wavelength for Treatment of Seasonal Affective Disorder

Clinical Trial Summary

The specific aim of this study is to test the hypothesis that light stimuli concentrated around 468 nm will evoke a significantly stronger therapeutic response in SAD patients compared to light stimuli concentrated around 654 nm at an equal photon density.

The secondary objective of this study is to determine the efficacy of different colors and levels of light in order to optimize therapeutic benefit, while also minimizing side effects and maintaining safety of light exposure.

Clinical Trial Description

Studies report as many as 1 out of every 5 Americans is affected by mild to severe Seasonal Affective Disorder (SAD, winter depression). Although the exact cause of this condition is unknown, bright light has proven to be an effective therapeutic treatment for many people with SAD. The light sources that have been traditionally used for treatment of SAD produce white light with great variability in the balance of wavelengths that are emitted across the visible spectrum. Although several studies have attempted to test the effectiveness of different wavelengths for treatment of SAD, the devices used in those studies employed broad bandwidths of light. With the technological advancements in light emitting diodes (LEDs) the production of new light therapy equipment with much narrower bandwidths of light is possible. Side effects of exposure to traditional white light therapy for SAD have included hypomanic activation, irritability, headache, eyestrain and nausea. We hypothesize that when the wavelength of light therapy is optimized, it should be feasible to elicit strong therapeutic benefits with lower light intensities and fewer side effects. Previous studies, approved by the Jefferson IRB and successfully completed by our laboratory have shown that some colors of light are more effective in treating SAD than other colors. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00269633
Study type Interventional
Source Thomas Jefferson University
Contact
Status Active, not recruiting
Phase Phase 2
Start date November 2006
Completion date November 2015
View Details
See also
  Status Clinical Trial Phase
Completed NCT00502320 - Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder Phase 4
Completed NCT00046241 - Prevention of Seasonal Affective Disorder Phase 3
Completed NCT00006517 - Clinical Trials of Three Non-Drug Treatments for Winter Depression (SAD) N/A
Active, not recruiting NCT03691792 - Optimizing Long-Term Outcomes for Winter Depression With CBT-SAD and Light Therapy N/A
Completed NCT01462058 - The Role of Vitamin D Supplementation on Well Being and Symptoms of Depression During the Winter Season in Health Service Staff Phase 4
Recruiting NCT01030276 - Bright Light Therapy in Seasonal Affective Disorder (SAD) N/A
Completed NCT01292889 - Study of Genes in Relation to Seasonal Affective Disorder and Major Depressive Disorder N/A
Completed NCT01149135 - Low Intensity 'Blue Light' Treatment of Seasonal Affective Disorder N/A
Completed NCT01048294 - Blue Enriched Versus Standard Light Treatment for Seasonal Affective Disorder(SAD) N/A
Completed NCT02582398 - Influence of Light Exposure on Cerebral MAO-A in Seasonal Affective Disorder and Healthy Controls Measured by PET N/A
Completed NCT01293409 - Bright Light Therapy in Seasonal Affective Disorder (SAD) N/A
Completed NCT00076245 - Cognitive Behavioral Therapy for the Treatment of Seasonal Affective Disorder (SAD) Phase 1
Completed NCT03313674 - Investigation of Seasonal Variations of Brain Structure and Connectivity in SAD N/A
Completed NCT00016666 - Clinical Trial of Propranolol for Seasonal Affective Disorder Phase 2
Recruiting NCT00114322 - Light-Emitting Diode (LED) Light for Seasonal Affective Disorder (SAD) Treatment N/A
Completed NCT00001485 - Effects of Season on Melatonin Secretion in Healthy Men and Women and Patients With Seasonal Affective Disorder N/A
Completed NCT01462305 - 30-Minute Light Exposure for the Treatment of Seasonal Affective Disorder N/A
Completed NCT00139997 - Environmental Treatment for Seasonal Affective Disorder (SAD) N/A
Completed NCT04251000 - Infrared Photomodulation Therapy for Seasonal Affective Disorder N/A
Completed NCT00809523 - A Trial of Negative Ion Generation Versus Light-Emitting Diode Phototherapy for Seasonal Affective Disorder (SAD) Phase 2/Phase 3