Evaluation of Low-Level Light Therapy on Meibomian Glands Study
The goal of this clinical trial is to examine the effect of low-level light therapy (LLLT) on meibomian gland dysfunction and dry eye disease. The main questions it aims to answer are: 1. Does low-level light therapy reduce levels of pro-inflammatory proteins in meibum 2. Does low-level light therapy increase the ratio of non-polar lipids to polar lipids in meibum Participants will receive 3 15-minute sessions of low-level light therapy. Meibum will be collected before the first treatment and after the final treatment.
NCT05859295 — Dry Eye
Status: Completed
http://inclinicaltrials.com/dry-eye/NCT05859295/
The Feasibility of Using Green Light Phototherapy for the Management of Acute Postoperative Pain
Researchers aim to demonstrate that the use of phototherapy is feasible and may reduce acute postoperative pain based on recent literature. The primary objective is to demonstrate that displaying light-emitting diodes [LED] can be achieved in the ICU setting in after cardiac surgery.
NCT05853731 — Cardiac Surgery
Status: Withdrawn
http://inclinicaltrials.com/cardiac-surgery/NCT05853731/
Light Therapy for Depression in Adolescent Outpatients: A Placebo lead-in Clinical Trial
The goal of this placebo lead-in clinical trial was to test bright light therapy (BLT) in adolescents with depression. The main question[s] it aimed to answer were: 1. characterize and define facilitators/barriers to treatment with BLT in adolescents); 2. evaluate the acceptability and feasibility of outpatient BLT in a dose titration protocol; 3. establish an effective, safe and tolerable light dose.
NCT05823090 — Depression
Status: Completed
http://inclinicaltrials.com/depression/NCT05823090/
Multicenter Study on the Role of Light Therapy in Modulating the Clinical Phenotype of Patients With Primary and Comorbid Chronic Insomnia Through Circadian Phase Modification.
Some evidence indicates that circadian rhythm may play a role in the pathophysiology of insomnia disorder. This single-blind randomized controlled multicentre prospective study aims to evaluate the possible therapeutic effect of light therapy in modulating the clinical phenotype of patients affected by chronic primary and comorbid insomnia, through the modification of the circadian phase.
NCT05797324 — Insomnia Chronic
Status: Recruiting
http://inclinicaltrials.com/insomnia-chronic/NCT05797324/
Repeated Low-level Red-light Therapy in High Myopia Children and Teenagers: a Prospective Single-arm Study
The purpose of this clinical trial is to investigate the incidence and magnitude of axial length shortening after repeated low-level red-light therapy in high myopia children and teenagers.
NCT05768152 — Eye Diseases
Status: Not yet recruiting
http://inclinicaltrials.com/eye-diseases/NCT05768152/
Clinical Study of Low Lever Red Light Therapy With 650nm to Control Myopia Progression in Children
Low-lever red light therapy (LLLT) has been used to control myopia progression in China for a few years besides amblyopia therapy for a few decades. This study is to test the efficacy of PBM therapy to myopia children as well as to compare two types of PBM therapy to control myopia progression within one month.
NCT05761379 — Myopia, Progressive
Status: Recruiting
http://inclinicaltrials.com/myopia-progressive/NCT05761379/
Effect of Low-Level Light Therapy Prior to Cataract Surgery: A Prospective, Randomized Controlled Study
The goal of this clinical trial is to evaluate the effectiveness of Low Level Light Therapy (LLLT) in reducing the incidence or alleviating the severity of DED due to meibomian gland dysfunction in otherwise healthy patients undergoing cataract surgery. Participants will be randomly assigned in a 1:1 ratio to either a treatment group or a control group. The treatment group will receive LLLT one week before and one week after cataract surgery; the control group will not recieve LLLT at any time. Researchers will compare the treatment and the control group to see if patients receiving LLLT present with reduced signs and symptoms of ocular surface dysfunction with respect to the control group.
NCT05754437 — Dry Eye
Status: Recruiting
http://inclinicaltrials.com/dry-eye/NCT05754437/
Assessment of Light Therapy in Insomnia Disorder
Sleep disorders represent a major public health issue and the leader in these disorders is insomnia with 10 to 15% of subjects in the general population reporting symptoms of insomnia with a daytime impact. In addition to being very common, insomnia leads to an increase in morbidity and mortality and weighs on healthcare systems worldwide. Despite this public health context, insomnia is underdiagnosed and rarely treated. Hypnotics have proven efficacy but with a risk of dependence and pharmacotolerance which appears within a few weeks. Cognitive behavioral therapy (CBT) has a good level of evidence and is now a benchmark treatment for the management of insomnia. Unfortunately, not all patients adhere to or respond to these procedures, which cannot be implemented for many of them either. There is therefore a need to identify other alternative therapeutic strategies, and we believe that exposure to light is a promising treatment. In this perspective, it seems interesting to assess the effect of the propensity to fall asleep with an exposure to light therapy in patients suffering from insomnia. In order to be in optimal ecological conditions, we want to use a portable light therapy device which allows easy, acceptable and ambulatory exposure. If the lighttherapy is confirmed in insomnia under ecological conditions, this would make it possible to propose a new non-drug treatment, easy to access and on a large scale
NCT05715411 — Insomnia
Status: Not yet recruiting
http://inclinicaltrials.com/insomnia/NCT05715411/
Bright Light Therapy for Post-COVID-19 Fatigue
This is a randomized placebo-controlled trial to examine the efficacy of two-week bright light therapy for patients with post-COVID-19 fatigue.
NCT05677932 — Post COVID-19 Condition
Status: Recruiting
http://inclinicaltrials.com/post-covid-19-condition/NCT05677932/
Promoting Cognitive Resilience and Reducing Frailty in Older Veterans With Bright Light Therapy
Frailty is a multifactorial syndrome characterized by vulnerability to stressors that is intricately linked to cognitive impairment and mortality risk. Bright light therapy (BLT) reduces circadian disturbances by resynchronizing the hypothalamic biological clock via specific wavelengths of light. Human trials have demonstrated that BLT improves sleep quality and cognitive function in older adults. However, BLT has not been examined for use in older Veteran populations, particularly the impact on frailty. This randomized trial will assess the feasibility of employing BLT to study impacts on frailty, cognition, and sleep in older Veterans. Findings from this pilot will establish the power and effect size necessary for larger trials to support the use of BLT as readily available home-based treatment to improve healthspan of Veterans.
NCT05631236 — Veteran Aged 65 and Older
Status: Recruiting
http://inclinicaltrials.com/veteran-aged-65-and-older/NCT05631236/