Scoliosis Clinical Trial
Official title:
The Effect of Magnesium Sulfate on Motor and Somatosensory Evoked Potentials in Children Undergoing Scoliosis Surgery
The primary objective of this study is to determine whether magnesium sulfate has a clinically important effect on the amplitude and latency of somatosensory and motor evoked potentials in patients undergoing surgical correction of idiopathic scoliosis.
Motor and somatosensory evoked potentials are continuously monitored in the setting of
scoliosis surgery to evaluate the integrity of spinal cord pathways. Detection of neural
irritation or injury using motor or somatosensory evoked potentials allows the surgeon to
modify technique to reverse the insult and proceed without spinal cord compromise. To
facilitate evoked potential monitoring, anesthetic agents that attenuate the evoked
responses must be avoided.Several different agents have been studied to try to diminish the
acute opioid tolerance and/or hyperalgesia seen with remifentanil.
Two studies investigated the effect of magnesium sulfate on intraoperative
remifentanil-induced hyperalgesia. In both studies, post-operative pain scores and opioid
consumption were decreased in those patients who received magnesium.
Our aim is to establish that magnesium sulfate does not adversely affect somatosensory
evoked potentials (SEPs) and motor evoked potentials (MEPs) in patients undergoing
correction of idiopathic scoliosis. Future clinical trials can then be performed
investigating the effect of magnesium sulfate on remifentanil-induced hyperalgesia in the
same population.
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Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
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