Scoliosis Clinical Trial
Official title:
Improving Low Bone Mass With Vibration Therapy for Girls With Adolescent Idiopathic Scoliosis (AIS) - A Randomized Controlled Trial
Verified date | July 2015 |
Source | Chinese University of Hong Kong |
Contact | n/a |
Is FDA regulated | No |
Health authority | Hong Kong: Department of Health |
Study type | Interventional |
This is a prospective randomized controlled trial investigating the effect of vibration therapy on bone mineral density (BMD) and bone quality in AIS subjects suffering from osteopenia (low bone mass).
Status | Completed |
Enrollment | 149 |
Est. completion date | December 2011 |
Est. primary completion date | December 2011 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 15 Years to 25 Years |
Eligibility |
Inclusion Criteria: - 15 to 25 year-old female patients suffering from clinically and radiologically diagnosed AIS - more than 18 months post-menarche and Risser's sign equal to or greater than 4, and fusion of epiphyseal plate of all phalanges and metacarpals of the left hand and wrist. - The Cobb's angle of the major structural curve is between 10 to 50 degrees (inclusive) - Z-score BMD of less than -1 Exclusion Criteria: - medical or musculoskeletal conditions that contraindicate or prevent the patients from receiving vibration therapy - subjects who are not willing to comply with the treatment protocol - subjects suffering from any medical conditions that affect bone metabolism such as hyperparathyroidism, hyperthyroidism, osteomalacia, acute or chronic renal or liver disease - treatment with medication that affects bone metabolism such as bisphosphonate, steroid. - pregnancy - history of spinal operation done for scoliosis - smokers or drinkers |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
China | Prince of Wales Hospital | Hong Kong SAR | Guangdong |
Lead Sponsor | Collaborator |
---|---|
Chinese University of Hong Kong |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Bone mineral density | 1 year | No | |
Secondary | Bone micro-architecture | 1 year | No |
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