Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT05262790 |
Other study ID # |
GMV-2013 |
Secondary ID |
|
Status |
Completed |
Phase |
|
First received |
|
Last updated |
|
Start date |
June 26, 2013 |
Est. completion date |
January 1, 2017 |
Study information
Verified date |
December 2021 |
Source |
Shanghai Mental Health Center |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational
|
Clinical Trial Summary
Schizophrenia is a heritable complex phenotype whose symptoms can be clustered into three
domains: positive symptoms, negative symptoms and cognitive impairments. Constellations of
negative symptoms in SCZ are composed of diminished motivation and pleasure, such as
asociality, anhedonia, and avolition, or diminished expressivity such as blunted affect and
alogia. Negative symptoms are associated with decreased quality of life and poor functional
outcomes. Although antipsychotics are generally effective on positive symptoms, they are
poorly effective on negative symptoms Currently, there are no licensed targeted medications
for negative symptoms. In view of these problems, considerable interest in identifying new
treatment targets for negative symptoms has grown over the past decade. Despite intense
efforts in brain imaging that have opened new opportunities for addressing these issues, the
neurobiological mechanism of negative symptoms remains unclear.
Structural brain measures from magnetic resonance imaging (MRI) are highly heritable and
representatively have high reproducibility and low measurement error. Prior neuroimaging
researches have consistently shown neuroanatomical abnormalities in the brains of individuals
with SCZ, with the most robust and consistent group-level structural differences in
widespread reduced volumes of hippocampal thalamus, amygdala and nucleus accumbens. SCZ have
been associated with widespread structural brain abnormalities, but results from neuroimaging
studies have been inconsistent.
Description:
Schizophrenia (SCZ) is a heritable complex phenotype whose symptoms can be clustered into
three domains: positive symptoms, negative symptoms and cognitive impairments. Constellations
of negative symptoms in SCZ are composed of diminished motivation and pleasure, such as
asociality, anhedonia, and avolition, or diminished expressivity such as blunted affect and
alogia. Negative symptoms are associated with decreased quality of life and poor functional
outcomes. Although antipsychotics are generally effective on positive symptoms, they are
poorly effective on negative symptoms Currently, there are no licensed targeted medications
for negative symptoms. In view of these problems, considerable interest in identifying new
treatment targets for negative symptoms has grown over the past decade. Despite intense
efforts in brain imaging that have opened new opportunities for addressing these issues, the
neurobiological mechanism of negative symptoms remains unclear.
Structural brain measures from magnetic resonance imaging (MRI) are highly heritable and
representatively have high reproducibility and low measurement error. Prior neuroimaging
researches have consistently shown neuroanatomical abnormalities in the brains of individuals
with SCZ, with the most robust and consistent group-level structural differences in
widespread reduced volumes of hippocampal thalamus, amygdala and nucleus accumbens. SCZ have
been associated with widespread structural brain abnormalities, but results from neuroimaging
studies have been inconsistent.