Schizophrenia Clinical Trial
Official title:
Effect of Anti-inflammatory Treatments on the Symptoms, Cognition, and Functioning of Adolescents With Schizophrenia
A double-blind controlled trial assessing the efficacy of anti-inflammatories on symptoms and cognition of adolescents with schizophrenia
Patients will be evaluated to confirm the diagnosis of schizophrenia, duration of the disease
and record a history of atopic diseases or recurrent infections throughout life. The PANSS,
PSP, and MCCB battery scales will be administered. A blood sample will be taken for the
determination of markers of inflammation before the start of pharmacological treatment.
Patients will start the antipsychotic medication assigned by their treating physician. They
will also be assigned randomly to the treatment arm. The study drug will be provided by the
research team under the presentation of capsules containing Celecoxib 200 mg, Minocycline 100
mg or Placebo, and patients will be instructed to take one capsule every 12 hrs daily.
The patient will be reassessed with PANSS, PSP, and MCCB after completing 6 weeks of
pharmacological treatment, type and dose of medication will be recorded and serum markers of
inflammation will be determined again.
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