Links Between Perception of Temporal Order Judgment and Causality in Schizophrenia

Schizophrenia Clinical Trial

— TOCAS  

Official title:

Study of the Links Between Perception of Temporal Order Judgment and Causality in Schizophrenic Spectrum Disorders

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03432000
• Other study ID #: 2017-A03019-44
• Status: Recruiting
• Phase: N/A
• Start date: February 1, 2018
• Est. completion date: December 31, 2022

Study information

• Verified date: August 2022
• Source: Hôpital le Vinatier
• Contact: MARTIN MD BRICE, PH
• Phone: 0033426738533
• Email: brice.martin[@]ch-le-vinatier.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

People with schizophrenia show disturbances in the perception of time. Among these alterations are the perturbations of the temporal order judgment. They are characterized by the fact that, as opposed to the general population, people with schizophrenia require a longer time interval between two successive stimuli to estimate which of the two events appeared first. If these alterations are now well documented, their consequences remain little explored. Among these consequences could however appear distortions of the judgment of causality (likely to underlie certain delusional interpretations) as well as a distressing experience of loss of the continuity of the lived experience (that could contribute to the alterations basic of self-awareness).

Description:

The objective of our work lies in the study of the links between temporal sequencing, subjective perception of time and causality. To carry out this work, the investigators will rely on an experimental paradigm (derived from Michotte's paradigm) which makes it possible to explore the links between temporal sequencing and perception of causality, validated in the normal subject. subjective consequences of these alterations will be explored using a phenomenological-inspired clinical scale (EAWE time-scale items)

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: December 31, 2022
• Est. primary completion date: September 30, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

Subjects with schizophrenia:

• Age from 18 to 45 years
• Diagnosis of schizophrenia according to DSM V criteria
• French mother tongue
• Psychotropic treatment unchanged during the month preceding the inclusion
• Stable symptomatology
• Normal or corrected visual acuity (> 0.8 at Snellen scale) and normal color vision
• Patients who gave informed consent to participate in the study

Control subjects (healthy volunteers):

• Age from 18 to 45 years
• Absence of neurological and psychiatric disorders
• French mother tongue

Exclusion Criteria:

• Recent addiction and abuse of cannabis or any other substance (according to DSM V criteria)
• Neurological disorders of vascular, infectious or neurodegenerative origin
• Taking somatic drugs with a cerebral or mental impact (eg corticosteroids)
• Disabling sensory disturbances, and in particular visual acuity
• Participation in a Neuro Cognitive Remediation Program
• Schizophrenia resistant to neuroleptic treatments
• Persons protected by law (pregnant women, minors, major under guardianship ...)

Related Conditions & MeSH terms

• Schizophrenia

Intervention

Other:
• Performances of patients and controls on temporal task
To carry out this work, we will rely on an experimental paradigm (derived from Michotte's paradigm) which makes it possible to explore the links between temporal sequencing and perception of causality, validated in the normal subject. subjective consequences of these alterations will be explored using a phenomenological-inspired clinical scale (EAWE time-scale items)

Locations

Country	Name	City	State
France	Vial Veronique	Bron	Rhone Alpes

Sponsors (1)

Lead Sponsor	Collaborator
Hôpital le Vinatier

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Comparison of the scores obtained by subjects with schizophrenia vs. the controls for the causal tasks, according to the delays between stimuli (stopping the moving launcher and appearance of the static object).	Michotte paradigm: evaluate the links (correlation) between perception of temporal sequencing and perception of causality using an adapted experimental paradigm	eight months
Secondary	Comparisons of the scores obtained on the Time Experiment Rating Examination of Anomalous World Experience Scale (EAWE).	Examination of Anomalous World Experience (EAWE ) scale:investigate the existence of a correlation between these alterations and the peculiarities of the subjective experience of time The E.A.W.E. consists of 6 dimensions (relation to space / relation to time / relation to others / language / atmospheric experience / existential orientation).The second domain only will be explored in our study Each item is both detailed, on a scale of 0 to 2 (0 for absent, 1 for present but with doubt, 2 for present, no doubt). The overall score of the sub-time scale thus ranges between 0 and 78.	eight months