Schizophrenia Clinical Trial
Official title:
Top Down Visual Information Processing in Schizophrenia Patients With Visual Hallucinations
Occurrence of visual hallucinations (VHs) in schizophrenia depend in part on disorders in the processing of late visual information (Top-Down). The broader question of how these top-down mechanisms (cognitive and / or emotional mechanisms) are involved in the occurrence of VHs remains to be specified and very few behavioral studies have so far been interested. The investigators propose to study the implication of Top-Down mechanisms in the visual hallucinatory manifestations, more specifically in the processing of ambiguous stimuli during an emotional priming task. Schizophrenia patients with VHs would have more false visual perceptions in the treatment of ambiguous stimuli than schizophrenia patients with auditory hallucinations or no hallucinations (AH/NH) and healthy controls.
In schizophrenia patients with auditory hallucinations, top-down mechanism on perceptual
processing could be illustrated by tasks of listening to white noise. These studies show that
psychotic subjects detect more words and phrases when exposed to these stimuli. In
schizophrenia patients with VHs, to our knowledge no study have explored the mechanism of
false perception. Thus, we propose to experimentally manipulate the implication of Top-Down
mechanisms on visual perception using an emotional priming task. This paradigm has already
been used in this population to explain the mechanisms underlying productive symptoms. For
example, in an emotional priming task authors have shown that a negative valence primer
contributes to the implementation of an interpretive bias in a confidence judgment task.
The aim of the present study is to explore the implication of these Top-Down mechanisms in
hallucinatory manifestations, more specifically on the treatment of ambiguous visual stimuli
during an emotional priming task by manipulating the emotional valence of the primer. The
goal is to determine how emotional environmental elements contribute to the formation of
erroneous perceptions in patients with schizophrenia with VHs.
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