Schizophrenia Clinical Trial
Official title:
Neurofunctional Basis of Emotion Processing: Clinical, Genetic, Biological and Imaging Study in Patients With Schizophrenia and Healthy Relatives of Patients in Comparison With a Control Group
Schizophrenia is an invalidating psychiatric illness with a strong genetic component
characterized by abnormal processing of emotional information. This alteration in emotion
processing has been described in acute as well as in remission phases of the illness. It has
also been found in healthy relatives of patients with schizophrenia and in subjects at high
risk of psychosis. Thus, alterations in emotional information processing are not only linked
to the prognosis but can also be considered as a marker of vulnerability of schizophrenia.
In addition, schizophrenia patients differ from healthy controls in neural activity in brain
regions implicated in emotions processing. However, interpretation of findings in patients
is limited by confounding factors, such as antipsychotic treatments or alterations due to
the course of illness. Also, there is no data concerning genetic factors (polymorphisms or
gene expression) underlying these patterns of cerebral activation in emotion information
processing.
So, the main objective of this study is to compare the cerebral activity of schizophrenia
patients to that of healthy siblings and healthy controls in an emotional processing task.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label
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