Validation of a Clinical Screening Grid for Syndromic Schizophrenia — Schizo-CGH-EXM  

Schizophrenia Clinical Trial

Official title: Validation of a Clinical Screening Grid for Syndromic Schizophrenia

Status Recruiting

Clinical Trial Summary

Background:

Nowadays, despite a large number of studies about schizophrenia and genetics, clinical red flags for syndromic forms of schizophrenia remain poorly documented.

Clinical Trial Description

Methods: This study aims to validate a short clinical screening grid for syndromic forms of schizophrenia linked to a pathogenic Copy Variation Number (CNV). The investigators plan to include 150 patients with defined (DSM V) schizophrenia and aged 15 years and more. The clinical grid will be prospectively fulfilled for every patients on the basis of his/her medical history and clinical examination. Array comparative genomic hybridization (CGH-a) will be performed on jugal mucosae sample to detect precisely syndromic forms of schizophrenia linked to the presence of a pathogenic Copy Number Variation (CNV).

In subjects with no CNV that may explain the onset of schizophrenia, the investigators would like to complete the investigations with exome trio sequencing. With this type of very clinical approach, the investigators wish to determine which semiological elements should alert the psychiatrists as to the presence of a syndromic form. The objective is to propose at the end of this study a simple and reliable scale, usable in psychiatry consultation, to guide the genetic screening of forms of syndromic schizophrenia. ;

Related Conditions & MeSH terms

• Schizophrenia

• NCT number: NCT02746510
• Study type: Interventional
• Source: Hôpital le Vinatier
• Contact: POISSON Alice, PH
• Phone: 00 33 4 37 91 51 63
• Email: alice.poisson@ch-le-vinatier.fr
• Status: Recruiting
• Phase: N/A
• Start date: July 2016
• Completion date: December 2023