Schizophrenia Clinical Trial
Official title:
Computerized Cognitive Training for Schizophrenia in Brazil
The purpose of this study is to investigate the effect of a neuroplasticity-based computerized cognitive training for people with schizophrenia in the Brazilian population.
Cognitive impairments are important determinants of functional outcome in schizophrenia,
which are inadequately treated by antipsychotic medication. Neuroplasticity based
computerized cognitive trainings have been emerging for the last two decades and are an
attempt to help patients with their cognitive impairments and global functioning.
The aim of this study is to perform a computerized cognitive training to improve attention,
concentration, learning, clinical symptoms and quality of life in patients. The investigators
are interested in testing the differential efficacy between a specific visual versus auditory
computerized cognitive training and explore the biological markers that may be involved in
these neuroplasticity based training processes.
The investigators will conduct a 40 hours computerized, adaptable, perception specific,
cognitive training program in patients with schizophrenia. Patients will come for 1 hour,
daily, and perform a visual or auditory training, or control games for about 2 months. Visual
and auditory exercises are chosen to be the equivalent of one another and target cognitive
domains such as divided attention, working memory and social cognition. Clinical, cognitive,
emotional and biomarker data will be collected before the training, half way through, and
after the training, to assess progress in several aspects of their functioning and biology.
The investigators hypothesize visual and auditory trainings will be effective as compared to
the control games. They also expect that auditory training to be more efficient compared to
the visual training because it targets sensory functions that are mostly impaired in
schizophrenia, due to auditory hallucinations patients experience. The investigators also
hypothesize that both trainings will improve clinical symptoms and quality of life. On a more
exploratory analysis, the investigators expect to identify new biological markers of
cognitive neuroplasticity, which they expect will differentiate visual and auditory paths.
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