Can we Forget? Directed Forgetting and Embodied Cognition in Schizophrenia

Schizophrenia Clinical Trial

Official title:

Can we Forget? Directed Forgetting and Embodied Cognition in Schizophrenia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02538445
• Other study ID #: 1001156
• Secondary ID: 2010-A01372-37
• Status: Completed
• Phase: N/A
• First received: August 31, 2015
• Last updated: March 22, 2016
• Start date: May 2011
• Est. completion date: December 2012

Study information

• Verified date: August 2015
• Source: Centre Hospitalier Universitaire de Saint Etienne
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)France: French Data Protection Authority
• Study type: Interventional

Clinical Trial Summary

Based on the theory of embodied cognition, which focuses on the influence of sensory and motor processes on cognition, researchers propose to study the influence of the action on memorization and inhibition in patients suffering from schizophrenia, using a directed forgetting paradigm. The directed forgetting paradigm is used, composed of two lists of action verbs. The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug. Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)). A recognition task is performed at the end. The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only. 48 schizophrenic patients were included in this study. Patients were randomized to have 10 participants per condition. 48 controls matched by age, gender, laterality and education are also included and randomized in the same modality. This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.

Description:

Researchers used the directed forgetting paradigm composed of two lists of action verbs. The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug. Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)). A recognition task is performed at the end. The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only. 48 schizophrenic patients were included in this study. Patients were randomized to have 10 participants per condition. 48 controls matched by age, gender, laterality and education are also included and randomized in the same modality. This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 96
• Est. completion date: December 2012
• Est. primary completion date: December 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria for patients:

• Schizophrenic patients as defined in Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV)

• Stabilized a therapeutic point of view for at least one month.

• Consent form signed

• Affiliated to a Security Health Program

Inclusion Criteria for volunteers:

• Consent form signed

• Affiliated to a Security Health Program

Exclusion Criteria for patients and volunteers :

• Not having a history of head trauma, neurological disease or not stabilized serious somatic illness,

• Not to use psychoactive substance, as defined by the DSM IV.

• The Intelligence Quotient must not be less than 70 (Progressive Matrices Standard score (PM38), Raven Progressive Matrix).

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Schizophrenia

Intervention

Other:
• Memorization of the verbs by miming the action
The participant reads aloud the verbs that appear on the screen, by performing the corresponding action verb.
• Memorization of the verbs by imagining the action
The participant reads aloud the verbs that appear on the screen, by imagining the corresponding action verb.
• Memorization of the action verbs by means of another word
The participant reads aloud the verbs that appear on the screen. Then, he reads, without memorizing it, a word associated with the action verb to be learnt to favor the memorization of that one. The word is written near the action verb.
• Simple memorization of the verbs
The participant reads aloud the verbs that appear on the screen, without additional instructions (control condition).

Locations

Country	Name	City	State
France	CHU de SAINT-ETIENNE	Saint Etienne

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Saint Etienne

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of items recalled TBR and TBF	It is asked to the participants to recall orally, only TBR verbs (task of reminder). The experimenter notes the given verbs.	Day 1	No
Secondary	Number of recognized items	Participants must recognize TBR verbs among several verbs (distractor or TBF verbs) on the screen.The experimenter notes the recognized verbs.; The recognition of a verb in the TBF list or a distractor is considered like an error.	Day 1	No
Secondary	Reaction time (ms) on the recognition of TBR and TBF	The response times of participants are recorded in ms.	Day 1	No