Schizophrenia Clinical Trial
Official title:
An Open-Label, Comparative Study of Immediate or Delayed Switch to Paliperidone Palmitate in Patients Unsatisfied With Current Oral Atypical Antipsychotics to Evaluate the Evolution of Medication Satisfaction and Adherence
The purpose of this study is to evaluate the change of medication satisfaction measured by Medication Satisfaction Questionnaire (MSQ) from baseline to endpoint for patients who are switched into paliperidone palmitate, either immediately or in a delayed mode.
This is a prospective (patients are first identified and then followed forward as time
passes), multicenter (study conducted at multiple sites), randomized (the study medication
is assigned by chance), comparative and open-labeled (all people know the identity of the
intervention) study.
The study mainly consists of 3 phases including, the screening phase (14 days before
administration of study medication), treatment phase, and the follow-up phase (28 days after
the last dose of the study medication). In the treatment phase, patients will be randomly
assigned equally in 2 groups (Group 1 and Group 2), on the basis of known and unknown
characteristics. Group 1 (immediate switch group): Patients will be administered with
paliperidone palmitate immediately after randomization and will continue throughout the
treatment phase. Group 2 (delayed switch group): Patients will remain on current oral
antipsychotics until Week 8, and later on will be completely switched to paliperidone
palmitate. However, during the first 8 weeks if the symptoms or satisfaction with MSQ
further deteriorates for Group 2, they may be switched into paliperidone palmitate earlier.
Safety evaluations will include evaluation of adverse events, clinical laboratory tests,
electrocardiogram, vital signs, and physical examination and these will be monitored
throughout the study.
The total duration of the study will be approximately 148 days.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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