Schizophrenia Clinical Trial
Official title:
Auditory Brainstem Response as a Diagnostic Tool in Schizophrenia and Bipolar Disorder
The purpose of this study is to study the predictive value of SensoDetect-BERA as a diagnostic tool in clinical practice for schizophrenia and bipolar disorder.
Background:
Within the daily clinical work of all medical specialties, objective diagnostic tools are
paramount. However, in the psychiatric field such measures are lacking. Since 1983 the
method of psychoacoustics has been under development in hope to serve this purpose. A recent
development of auditory brainstem response (ABR/SD-BERA), has been proposed as a potential
diagnostic tool within psychiatry.
The ABR is a diagnostic tool used primarily to diagnose sensorineural hearing loss. It
detects evoked potentials, generated by neuronal activity in the auditory pathways in the
brainstem, within the first 10 ms following acoustic stimulation. The potentials are
recorded by surface electrodes placed on the forehead and on the mastoid processes. The wave
pattern recorded consists of seven peaks, which are interpreted with respect to latencies
and amplitudes.
Previous studies have aimed to associate the peaks with specific anatomical structures. The
method SD-BERA is a further development of the standard ABR. It uses a wider array of
acoustic stimuli, including complex sounds, for instance masking noises. The measuring
procedure will roughly take 25 minutes. Previous studies using these complex sounds to
compare mentally healthy subjects with patients suffering from schizophrenia, ADHD and
bipolar disorder have shown that the different psychiatric groups exhibit specific wave
patterns.
Aims
The aim of the first study is to validate previous results and identify five (n=5) patients
with diagnosed ADHD, schizophrenia and bipolar disorder, and to compare these patients
(n=15) with healthy, age-matched controls.
The aim of the second study is to present a blinded study where 12 patients with
schizophrenia and 12 patients with bipolar disorder (total n=24) are compared to each other
and to healthy controls (n=12) in order to evaluate the method as a diagnostic tool in
clinical healthcare practice.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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