Schizophrenia Clinical Trial
Official title:
Specific Versus General Cognitive Remediation for Schizophrenia
Rationale:
Cognitive deficits are a core feature in schizophrenia. Conventional treatments
(antipsychotic medication and psychological treatments) have limited effects so cognitive
remediation programs were designed to alleviate the problems. Interventions typically
involve a variety of exercises in a paper and pencil or a computerized format with a growing
number of specialized computer programs now being developed. However, many of these programs
lack specificity which does not allow an individual's specific needs to be addressed. More
targeted interventions might increase the effects of therapy so RECOS - COgnitive
REmediation for Schizophrenia - was developed to fit this gap.
Methods: This is a multicenter, randomized, controlled study comparing patients aged 18 to
45 years suffering from schizophrenia according to DSM-IV-TR. RECOS will be compared to an
already validated program (CRT).
220 patients will be randomized as follows :
- Arm 1 : RECOS (42 h)
- Arm 2 : CRT (42 h) The recruitment is performed by psychiatrists in Lyon, Paris,
Clermont-de-l'Oise, Niort, Bordeaux, Ville-Evrard and Lausanne.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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