Salsalate as an Adjunctive Treatment for Patients With Schizophrenia

Status Completed

Clinical Trial Summary

This is a 12-week, open-label trial of salsalate 3 g/day as an adjunctive treatment in 15 schizophrenia subjects to examine salsalate's effect on psychopathology, cognitive functioning, and metabolic parameters.

Potential subjects will be identified by their clinicians at the Freedom Trail Clinic, or Massachusetts General Hospital. A total of 15 subjects will be enrolled.

Clinical Trial Description

The specific aims include:

Primary aims:

1. Examine the efficacy of salsalate (3g/day) in improving positive and negative symptoms as measured by the Positive and Negative Syndrome Scale (PANSS) and the Scale for Assessment of Negative Symptoms (SANS).

2. Examine the efficacy of salsalate in improving cognition as measured by the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) composite score.

Secondary aims:

1. Examine salsalate's effects on inflammatory markers such as high sensitivity C-reactive protein (hs-CRP), TNF-α and IL-6. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01578486
Study type	Interventional
Source	University of Massachusetts, Worcester
Contact
Status	Completed
Phase	Phase 4
Start date	June 2011
Completion date	July 2015

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