Schizophrenia Clinical Trial
Official title:
Mitochondria and Schizophrenia: Effects of Antipsychotic Drugs
Verified date | September 2013 |
Source | Chang Gung Memorial Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | Taiwan: Department of Health |
Study type | Observational |
The investigators will investigate
1. the relationships between oxidative stress-, apoptosis-related markers, mitochondria
DNA copy numbers and the clinical psychopathology of schizophrenia, including severity
of positive and negative symptoms, obesity and metabolic syndrome.
2. the relationships between aberrant mitochondria genes (single nucleotide polymorphism
of D-loop region-related genes and haplogroup N9a), DISC1 gene polymorphism, and
clinical phenotypes in Taiwanese populations.
3. whether these biological markers could be as clinical markers in schizophrenia for a
long-term follow-up study.
Status | Completed |
Enrollment | 77 |
Est. completion date | September 2013 |
Est. primary completion date | July 2012 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: 1. Schizophrenic patients will be recruited in psychiatric inpatients and outpatients departments according to DSM-IV criteria by a semi-structured interview. The assessment will be done by two senior psychiatrists. The intra- rater and inter-rater reliability will be done before this project started. 2. The patients had the ability to complete the written inform consent. Exclusion Criteria: 1. Alcohol abuse or dependence 2. Smoking more than 1 pack per day 3. Concurrent use of mood stabilizer or beta-blocker |
Observational Model: Case-Only, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Taiwan | Department of Psychiatry, Chang Gung Memorial Hospital | Kaohsiung |
Lead Sponsor | Collaborator |
---|---|
Chang Gung Memorial Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Serum oxidative stress | serum malondialdehyde (MDA) content, serum free thiols, serum glutathione, catalase, Superoxide dismutase, glutathione peroxidase, proapoptotic markers (bad and bax) and antiapoptotic markers (bcl-2 and bcl-x1), quantification of mitochondrial DNA | 15 months | Yes |
Primary | DISC1 gene polymorphism | 15 months | Yes | |
Secondary | PANSS score | Positive and Negative Syndrome Scale to reflect the severity of psychopathology | 15 months | Yes |
Secondary | Obesity | obesity defined by body mass index (BMI)>=26.4 | 15 months | No |
Secondary | Metabolic syndrome | 15 months | No | |
Secondary | Drug response | 15 months | Yes |
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