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NCT01427088 Clinical Trial

rTMS-induced Cumulative Pattern of sBDNF in Chronic Schizophrenia

Schizophrenia Clinical Trial

Official title:
Short-Term Response of Serum Brain-Derived Neurotrophic Factor to Repetitive Transcranial Magnetic Stimulation in Patients With Chronic Schizophrenia

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01427088
Other study ID # rTMS-sBDNF-SPR-2011
Secondary ID
Status Completed
Phase N/A
First received August 28, 2011
Last updated February 15, 2015
Start date August 2011
Est. completion date November 2011

Study information
Verified date February 2015
Source Jeonbuk Provincial Maeumsarang Hospital
Contact n/a
Is FDA regulated No
Health authority Korea: Institutional Review Board
Study type Interventional

Clinical Trial Summary

This study aims at investigating the neuroplastic potential and the possible factors affecting rehabilitation in chronic schizophrenia patients on stable medication, by investigating the cumulative pattern of serum BDNF representing the neuroplasticity in the brain, through quantitative stimulus such as rTMS.

Description:

Subjects who have been enrolled for this study will take baseline evaluation for sociodemographic data and serum level of BDNF, plasma Prolaction, and magnesium, etc. And then, weekday regular stimulation through rTMS will be applied on DLPFC of brain. After the completion of stimulation for 2 weeks, the change or response of serum BDNF will be analyzed and compared.

Recruitment information / eligibility
Status Completed
Enrollment 21
Est. completion date November 2011
Est. primary completion date October 2011
Accepts healthy volunteers No
Gender Both
Age group 25 Years to 60 Years
Eligibility Inclusion Criteria:

- duration of illness over 10 years

- on stable medication, antipsychotics

- no change on medication within at least 2 weeks

- Diagnosis of Schizophrenia according to DSM-IV-TR

Exclusion Criteria:

- left or both-handedness

- anticonvulsant use

- lorazepam equivalent over 3 mg

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Intervention

Device:
• CR Technology, TAMAS for repetitive TMS
repetitive TMS, lef DLPFC, 20Hz, 100% of MEP, 2weeks

Locations
Country Name City State
Korea, Republic of Jeonbuk Provincial Maeumsarang Hospital Wanju Jeonbuk

Sponsors (1)
Lead Sponsor Collaborator
Jeonbuk Provincial Maeumsarang Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Primary change from baseline of serum BDNF concentration baseline-1 week-2 week-4 week No
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