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Nicotinic Receptors and Schizophrenia

Schizophrenia Clinical Trial

Official title:
Nicotinic Receptors and Schizophrenia: Phase II

Clinical Trial Summary

The investigators hypothesize that sustained-release DMXB-A-SR (3-2,4 dimethoxybenzylidene anabaseine sustained release) will provide clinical improvement in cognition in patients with schizophrenia who are smokers and who are non-smokers. The study drug may also maintain abstinence from cigarette smoking and improve other symptoms in patients with schizophrenia.

Clinical Trial Description

Patients with schizophrenia will be screened then enrolled for one week placebo trial in addition to their existing antipsychotic medication. If pill compliance is greater than 80%, then they will receive baseline clinical, cognitive, and brain imaging and all clinical laboratory examinations and a physical examination, vital signs, and cardiogram. Then patients will receive in a randomized double blind trial either DMXB-A-SR (3-2,4 dimethoxybenzylidene anabaseine sustained release) or placebo comparator in addition to their existing antipsychotic medication. After one month patients will receive repeat clinical, cognitive, and brain imaging testing and all clinical laboratory examinations and a physical examination, vital signs, and cardiogram. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01400477
Study type Interventional
Source University of Colorado, Denver
Contact
Status Completed
Phase Phase 2
Start date July 2011
Completion date June 2015
View Details
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