Schizophrenia Clinical Trial
Official title:
Default Network Dysfunction Underlying Visuospatial Attention Deficits in Schizophrenia
Background:
- A special brain circuit is important for helping us keeping an eye open for things that are
going on around us, even when we are not directly paying attention to them. This circuit
seems to work differently in people with schizophrenia than in other people, which may
explain specific deficits with broad monitoring observed in people with schizophrenia.
Researchers want to compare brain function in people with schizophrenia and healthy
volunteers to find out more about how these brain circuits work and affect attention.
Objectives:
- To study how the brain performs broad visual monitoring in people with schizophrenia.
Eligibility:
- Individuals between 18 to 55 years of age who have been diagnosed with schizophrenia.
- Healthy volunteers between 18 and 55.
Design:
- Participants will be screened with physical and psychological exams. They will have a
medical history. Tests for drug and alcohol use will also be done.
- Participants will have two study visits. The first is a training visit and the second is
a scanning visit.
- At the training visit, participants will practice computer-based tests of focus, memory,
and concentration. They will also answer questions about mood, psychiatric symptoms, and
smoking habits.
- At the scanning visit, participants will perform the computer-based tasks that they
practiced at the training visit. They will have magnetic resonance imaging while they
perform these tasks.
Objective: To test a neural circuit explanation for a visuospatial attention abnormality seen
in schizophrenia. Specifically, the aim is to test whether broad monitoring deficits may be
based on a disruption of the so-called sentinel function of the default network. Because the
default network is modulated by nicotinic compounds, such finding would implicate a possible
remediation strategy.<TAB>
Study population: 24 people with schizophrenia, 24 matched healthy control subjects.
Design: A group comparison of attention task performance and associated brain activity as
measured by functional Magnetic Resonance Imaging.
Outcome measures: Measures of attention task performance (reaction time, accuracy), BOLD
signal within regions of the default network, degree of temporal association of BOLD signal
with trial-by-trial reaction time.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05039489 -
A Study on the Brain Mechanism of cTBS in Improving Medication-resistant Auditory Hallucinations in Schizophrenia
|
N/A | |
Completed |
NCT05111548 -
Brain Stimulation and Cognitive Training - Efficacy
|
N/A | |
Completed |
NCT05321602 -
Study to Evaluate the PK Profiles of LY03010 in Patients With Schizophrenia or Schizoaffective Disorder
|
Phase 1 | |
Completed |
NCT04503954 -
Efficacy of Chronic Disease Self-management Program in People With Schizophrenia
|
N/A | |
Completed |
NCT02831231 -
Pilot Study Comparing Effects of Xanomeline Alone to Xanomeline Plus Trospium
|
Phase 1 | |
Completed |
NCT05517460 -
The Efficacy of Auricular Acupressure on Improving Constipation Among Residents in Community Rehabilitation Center
|
N/A | |
Completed |
NCT03652974 -
Disturbance of Plasma Cytokine Parameters in Clozapine-Resistant Treatment-Refractory Schizophrenia (CTRS) and Their Association With Combination Therapy
|
Phase 4 | |
Recruiting |
NCT04012684 -
rTMS on Mismatch Negativity of Schizophrenia
|
N/A | |
Recruiting |
NCT04481217 -
Cognitive Factors Mediating the Relationship Between Childhood Trauma and Auditory Hallucinations in Schizophrenia
|
N/A | |
Completed |
NCT00212784 -
Efficacy and Safety of Asenapine Using an Active Control in Subjects With Schizophrenia or Schizoaffective Disorder (25517)(P05935)
|
Phase 3 | |
Completed |
NCT04092686 -
A Clinical Trial That Will Study the Efficacy and Safety of an Investigational Drug in Acutely Psychotic People With Schizophrenia
|
Phase 3 | |
Completed |
NCT01914393 -
Pediatric Open-Label Extension Study
|
Phase 3 | |
Recruiting |
NCT03790345 -
Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics
|
Phase 2/Phase 3 | |
Recruiting |
NCT05956327 -
Insight Into Hippocampal Neuroplasticity in Schizophrenia by Investigating Molecular Pathways During Physical Training
|
N/A | |
Terminated |
NCT03261817 -
A Controlled Study With Remote Web-based Adapted Physical Activity (e-APA) in Psychotic Disorders
|
N/A | |
Terminated |
NCT03209778 -
Involuntary Memories Investigation in Schizophrenia
|
N/A | |
Completed |
NCT02905604 -
Magnetic Stimulation of the Brain in Schizophrenia or Depression
|
N/A | |
Recruiting |
NCT05542212 -
Intra-cortical Inhibition and Cognitive Deficits in Schizophrenia
|
N/A | |
Completed |
NCT04411979 -
Effects of 12 Weeks Walking on Cognitive Function in Schizophrenia
|
N/A | |
Terminated |
NCT03220438 -
TMS Enhancement of Visual Plasticity in Schizophrenia
|
N/A |