Schizophrenia Clinical Trial
Official title:
Randomized, Double-blind, Parallel Trial Comparing the Effects of Eltoprazine (Adjunct to Anti-psychotics) With Placebo in Adults With Schizophrenia, in Improving One or More Dimensions of Cognitive Impairment Associated With Schizophrenia
The purpose of this study is to determine if eltoprazine (as an adjunct to anti-psychotic medication) improves one or more aspects of cognitive impairment in adult schizophrenic patients.
Schizophrenia is a common and highly disabling psychiatric disorder with population
prevalence around 1%. The manifestations of schizophrenia fall into three major domains: 1)
"positive" symptoms, such as delusions, hallucinations, and disorganization of behavior; 2)
"negative symptoms," including social withdrawal, lack of motivation, and reduced expression
of affect; and 3) cognitive dysfunction. Cognitive deficits are seen in most patients with
schizophrenia.
Eltoprazine has agonist effects on both 5-HT1A and 5-HT1B receptors, which suggests that this
drug may be useful for normalizing prefrontal cognitive abilities, reducing aggression and
impulsivity, and improving cognitive function in schizophrenia.
This study will compare the effects of Eltoprazine (as an adjunctive treatment to
anti-psychotics) with Placebo in Adults with a DSM IV/DSM IV TR diagnosis of schizophrenia,
in potentially improving one or more dimensions of cognitive impairment associated with
schizophrenia.
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